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The PlA1/PlA2 polymorphism lies within the gene for your β3 (GPIIIa) subunit of αIIbβthree (GPIIb-IIIa). This integrin serves being a receptor for adhesive proteins fibrinogen and von Willebrand variable and is particularly crucial with the cohesive Qualities of platelets. Recognition of such proteins as soluble ligands necessitates αIIbβthree